It is widely accepted that T-cell mediated immune response is involved in the pathogenesis of multiple sclerosis (MS).

We studied association between T cell immunoglobulin % and mucin domain 3 (Tim3)-pos T cells and related cytokines and MS.

Percentage Tim3-pos T cells in CD4⁺ and CD4⁺CD25⁺ T cell subsets were significantly lower among MS patients than controls.

Proportions of CD4⁺Tim3⁺ and CD4⁺CD25⁺Tim3⁺ cells in PBMCs were significantly lower in the MS group than the control group.

Serum concentrations of galectin-9, IL-17, and IFN-γ were increased in MS patients compared with controls.