Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
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- 作者：Y. Joy Yu Zuchero1 ; 8 ; joy.yu929@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Xiaocheng Chen2 ; 8 ; Nga Bien-Ly1 ; Daniela Bumbaca3 ; Raymond K. Tong4 ; Xiaoying Gao5 ; Shuo Zhang1 ; Kwame Hoyte5 ; Wilman Luk5 ; Melanie A. Huntley6 ; Lilian Phu4 ; Christine Tan2 ; Dara Kallop7 ; Robby M. Weimer7 ; Yanmei Lu5 ; Donald S. Kirkpatrick4 ; James A. Ernst4 ; Ben Chih5 ; chih.ben@gene.com" class="auth_mail" title="E-mail the corresponding author ; Mark S. Dennis2 ; Ryan J. Watts1
- 刊名：Neuron
- 出版年：2016
- 出版时间：6 January 2016
- 年：2016
- 卷：89
- 期：1
- 页码：70-82
- 全文大小：2604 K
文摘
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Limited antibody uptake in brain for low-expressing targets at the BBB
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Proteomic analysis reveal highly expressed proteins at the BBB
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Brain uptake of antibodies against highly abundant BBB targets follows in vivo dosing
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CD98hc is a robust and novel BBB target for antibody therapeutics for CNS diseases