E2F1-CDK1 pathway activation in kanamycin-induced spiral ganglion cell apoptosis and the protective effect of CR8
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- 作者：Yu-ying Liua ; b ; Guo-peng Wangc ; Zhe Pengc ; Jing-ying Guoc ; Qian Wuc ; Jing Xiec ; Shu-sheng Gongc ; gongss1962@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cochlear ; Spiral ganglion cells ; Apoptosis ; E2F1 ; CDK1 ; CR8
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：617
- 期：Complete
- 页码：247-253
- 全文大小：2384 K
文摘
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Activation of the E2F1-CDK1 pathway and cell cycle re-entry contributes to the apoptosis of spiral ganglion cells (SGCs).
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CR8 inhibits the E2F1-CDK1 pathway and down-regulates cleaved caspase-9 to potentially protect SGCs from apoptosis.
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This is the first study focusing on the E2F1-CDK1 pathway and cell cycle re-entry in SGC apoptosis.