Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues
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- 作者：Hiroyuki Makiharaa ; b ; Hironori Inabaa ; 1 ; Atsushi Enomotoc ; 1 ; Hiroki Tanakaa ; 1 ; Yasuko Tomonod ; Kaori Ushidac ; Mitsuo Gotob ; Kenichi Kuritab ; Yoshihiro Nishidae ; Kousuke Kasaharaa ; f ; Hidemasa Gotoa ; g ; hgoto@aichi-cc.jp" class="auth_mail" title="E-mail the corresponding author ; Masaki Inagakia ; f ; minagaki@doc.medic.mie-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Desmin ; Intermediate filament ; Phosphorylation ; Mitosis ; Cdk1
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1323-1329
- 全文大小：2510 K
文摘
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Cdk1 phosphorylates desmin, a myogenic intermediate filament (IF) protein.
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Desmin phosphorylation by Cdk1 is detected especially during mitosis.
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Cdk1-induced phosphorylation is required for efficient segregation of desmin-IFs.
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Desmin phosphorylation by Cdk1 is detected in muscular mitotic cells in vivo.