Human serum determination and in vitro anti-inflammatory activity of the vitamin E metabolite α-(13'-hydroxy)-6-hydroxychroman
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- 作者：Silvia Ciffolillia ; 1 ; Maria Wallertb ; 1 ; Desiré ; e Bartolinia ; Verena Krauthc ; Oliver Werzc ; Marta Piroddia ; Bartolomeo Sebastianid ; Pierangelo Torquatoa ; b ; Stefan Lorkowskib ; 2 ; Marc Birringere ; 2 ; Francesco Gallia ; 2 ; francesco.galli@unipg.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：LCM ; long-chain metabolite ; TOH ; tocopherol ; T3 ; tocotrienol ; TQ ; tocopheryl quinone ; α-13&prime ; -OH ; α-13&prime ; -(6-hydroxy-2 ; 5 ; 7 ; 8 ; -tetramethylchroman-2-yl)-2 ; 6 ; 10-trimethyltridecanol ; α-13&prime ; -COOH ; α-13&prime ; -(6-hydroxy-2 ; 5 ; 7 ; 8 ; -tetramethylchroman-2-yl)-2 ; 6 ; 10-trimethyltridecanoicacid ; CEHC ; 2&rsquo ; -carboxyethyl)-6-hydroxychroman ; α-TTP ; α-tocopherol transfer protein ; iNOS ; inducible form of nitric oxide synthase ; COX2 ; cyclooxygenase-2
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：Complete
- 页码：952-962
- 全文大小：1507 K
文摘
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An original HPLC and GC-MS procedure to measure serum α-13-OH, the earliest metabolite ofvitamin E, is proposed.
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Baseline levels of α-13-OH (gt; 10 nM) steadily increase by 2 to 7 times after 1-week supplementation with high doses of RRR-α-tocopherol.
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This metabolite modulates key inflammatory pathways in macrophages in vitro.