Analytical strategies to assess the functional metabolome of vitamin E
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- 作者：Pierangelo Torquatoa ; 2 ; Orsola Ripaa ; 2 ; Danilo Giusepponib ; 2 ; Roberta Galarinib ; 1 ; Desiré ; e Bartolinia ; Maria Wallertc ; Roberto Pellegrinod ; Gabriele Crucianid ; Stefan Lorkowskie ; f ; Marc Birringerg ; Francesco Mazzinih ; Francesco Gallia ; 1 ; francesco.galli@unipg.it" class="auth_mail" title="E-mail the corresponding author ; roosters2110@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：LCM ; long-chain metabolite ; T ; tocopherols ; T3 ; tocotrienols ; NGT ; RRR-5-nitro-γ-tocopherol ; TQ ; tocopheryl quinone ; TQE1 ; epoxyquinon 1 ; TQE2 ; epoxyquinon 2 ; THQ ; tocopherolhydroquinone ; CEHCs ; carboxyethyl hydroxychromans ; α-13&prime ; OH ; α-13&prime ; -(6-hydroxy-2 ; 5 ; 7 ; 8 ; -tetramethylchroman-2-yl)-2 ; 6 ; 10-trimethyltridecanol ; α-13&prime ; COOH ; α-13&prime ; -(6-hydroxy-2 ; 5 ; 7 ; 8 ; -tetramethylchroman-2-yl)-2 ; 6 ; 10-trimethyltridecanoicacid ; ESI-MS ; electrospray mass spectrometry ; FL ; fluorescence ; ELSD ; evap
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：30 May 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：399-412
- 全文大小：2325 K
文摘
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The human “endometabolome” of vitamin E has been recently deciphered.
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Vitamin E metabolism generates bioactive compounds with cellular functions.
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Immunomodulatory and anti-atherogenic properties of LCMs have been recently demonstrated.
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The analytical strategy to assess vitamin E metabolites in human blood is described.
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An unbiased LC-APCI-MS/MS method to quantify LCMs in human serum is preliminarily reported.