A Cyclin D2-derived peptide acts on specific cell cycle phases by activating ERK1/2 to cause the death of breast cancer cells

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• 作者：Lilian C. Russo^a ; Christiane B. Araujo^b ; ^c ; Leo K. Iwai^c ; Emer S. Ferro^b ; Fabio L. Forti^a ; ^{flforti@iq.usp.br}
• 关键词：Pep5 ; Cell death ; Breast cancer cells ; ERK1/2 activation ; Cell cycle ; Cyclin D2
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：16 January 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：24-32
• 全文大小：1227 K
• 卷排序：151

文摘

Cyclin D2-derived peptide pep5 induces cell death in MDA-MB-231 breast cancer cells. Cell death is more pronounced when pep5 is added on G1/S transition or S phase. Mass spectrometry identified several intracellular proteins interacting with pep5. Pep5 interactors are mainly involved with cytoskeleton and proteasome regulation. Pep5-promoted cell death seems to be dependent on ERK activation, PLEC and CLIC1.