Can increased visceral adiposity without body weight changes accelerate carotid atherosclerosis in South Korean participants with type 2 diabetes?

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• 作者：Chul Sik Kim^a ; ^b ; ¹ ; Soo-Kyung Kim^c ; Maria Rosario G. Araneta^b ; Eun Jig Lee^d ; ^{EJLEE423@yuhs.ac" class="auth_mail" title="E-mail the corresponding author} ; Elizabeth Barrett-Connor^b ; ^{ebarrettconnor@ucsd.edu" class="auth_mail" title="E-mail the corresponding author} ; Kab Bum Huh^e ; ^{huh7181827@hanmail.net" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Carotid atherosclerosis ; Carotid intima-media thickness ; Obesity ; Type 2 diabetes mellitus ; Visceral fat thickness
• 刊名：Journal of Diabetes and its Complications
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：29
• 期：8
• 页码：1085-1091
• 全文大小：356 K

文摘

Type 2 diabetes mellitus (T2DM) and visceral obesity are associated with each other and with cardiovascular diseases. We determined whether increased visceral adiposity without weight gain was associated with sex-specific accelerated carotid atherosclerosis in South Koreans with T2DM.

Methods

From 2003 to 2012, we recruited 280 participants with T2DM for the Seoul Metabolic Syndrome cohort who had body weight, visceral fat thickness (VFT), and carotid intima-media thickness (CIMT) measured at intervals of 2 years. According to VFT change, sex-specific quartiles of clinical characteristics and changes of CIMT were determined. Logistic regression models predicted the odds of the progression of CIMTs in each quartile.

Results

During 2 years of observation, VFTs fell by 5.2 ± 13.5 mm in men (P < 0.001) and 3.4 ± 10.5 mm in women (P < 0.001). Progression of CIMT was only significant for women's maximal CIMT (0.031 ± 0.145 mm, P = 0.012), while significant improvements in HbA1c were found (0.9%; P < 0.001 in both sexes). There were no significant differences in clinical characteristics, or in progression of CIMT in men or women according to 2-year quartiles of VFT change.

Conclusions

Our results do not suggest that increased visceral adiposity without body weight changes impacts the CIMT progression in South Korean men or women with T2DM.