The 46 kDa dimeric protein from Variovorax paradoxus shows faster methotrexate degrading activity in its nanoform compare to the native enzyme
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- 作者：Venkata Krishna Bayineni ; Krishna Venkatesh ; Chandan Kumar Sahu ; Ravi-Kumar Kadeppagari ; ravikadeps@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Methotrexate ; Variovorax paradoxus ; Cancer ; Casein ; Gelatin ; Enzyme nanoparticles
- 刊名：Enzyme and Microbial Technology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：38-43
- 全文大小：722 K
文摘
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Methotrexate degrading enzyme of Variovorax paradoxus is a dimeric 46 kDa protein.
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Enzyme nanoparticles degrade methotrexate faster than the native enzyme.
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Enzyme nanoparticles show lower Km compare to the native enzyme.
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Enzyme nanoparticles show better serum stability compare to the native enzyme.
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Enzyme nanoparticles show better functionality compare to the native enzyme.