The Dynamics of Apoptotic Cell Clearance
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- 作者：Michael R. Elliott<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>michael_elliott@urmc.rochester.edu" class="auth_mail" title="E-mail the corresponding authorsup> ; Kodi S. Ravichandran<sup>3sup><sup> ; sup><sup>4sup><sup> ; sup><sup>5sup><sup> ; sup><sup>ravi@virginia.edu" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：phagocytosis ; apoptosis ; efferocytosis ; chemotaxis ; imaging ; signal transduction ; immunity
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：38
- 期：2
- 页码：147-160
- 全文大小：1120 K
文摘
The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.