PCAF inhibits hepatocellular carcinoma metastasis by inhibition of epithelial-mesenchymal transition by targeting Gli-1
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- 作者：Qing Li ; Zhikui Liu ; Meng Xu ; Yumo Xue ; Bowen Yao ; Changwei Dou ; Yuli Jia ; Yufeng Wang ; Kangsheng Tu ; tks0912@foxmail.com" class="auth_mail" title="E-mail the corresponding author ; Xin Zheng ; xin.zheng.xjtu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yingmin Yao ; yaoyingmin@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatocellular carcinoma ; EMT ; PCAF ; Tumor invasion ; Gli1
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 May 2016
- 年：2016
- 卷：375
- 期：1
- 页码：190-198
- 全文大小：3201 K
文摘
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PCAF is low-expressed in 51.4% of resected HCC tissues by immunohistochemistry.
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Clinicopathological data showed decreased PCAF was associated with HCC metastasis.
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PCAF may inhibit HCC metastasis through induced EMT via modulating Gli1 expression.