Structural Titration of Slo2.2, a Na<sup>+sup>-Dependent K<sup>+sup> Channel

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• 作者：Richard K. Hite<sup>1sup> ; Roderick MacKinnon<sup>1sup><sup> ; sup><sup>2sup><sup> ; sup><sup>mackinn@rockefeller.edusup>
• 关键词：K+ channel ; ligand-gated ion channel ; cryo-electron microscopy ; molecular structure ; ion channel gating ; high conductance K+ channel ; Slo2 channel ; channel gating mechanism
• 刊名：Cell
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：168
• 期：3
• 页码：390-399.e11
• 全文大小：8701 K
• 卷排序：168

文摘

Cryo-EM and functional titrations of Slo2.2 Structures of Slo2.2 in open and closed conformations Switch-like activation mechanism between open and closed conformations Evidence of non-conductive channels in an open conformation