Syntheses, structure characterization and dissolution of two novel cocrystals of febuxostat

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• 作者：Yanlei Kang^a ; Jianming Gu^b ; Xiurong Hu^b ; ^{huxiurong@zju.edu.cn}
• 关键词：Febuxostat ; Cocrystal ; Syntheses ; Structure ; Dissolution
• 刊名：Journal of Molecular Structure
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：1130
• 期：Complete
• 页码：480-486
• 全文大小：1441 K
• 卷排序：1130

文摘

Two novel cocrystals (febuxostat-isonicotinamide and febuxostat-arginine) were discovered. The crystal structure of febuxostat-isonicotinamide was solved. Both febuxostat cocrystals showed an improved dissolution profile compared to pure febuxostat.