Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk

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• 作者：Guan-Huei Lee¹ ; ² ; ³ ; ^{mdcleegh@nus.edu.sg" class="auth_mail" title="E-mail the corresponding author} ; Boon-Huan Tan⁴ ; Esmeralda Chi-Yuan Teo⁵ ; Seng-Gee Lim¹ ; ² ; ³ ; Yock-Young Dan¹ ; ² ; ³ ; Aileen Wee¹ ; ⁶ ; Pauline Poh Kim Aw⁷ ; Yuan Zhu⁷ ; Martin Lloyd Hibberd⁷ ; ⁸ ; Chee-Kiat Tan⁹ ; ¹⁰ ; Michael A. Purdy¹¹ ; Chong-Gee Teo¹¹
• 关键词：Case Study ; Liver Disease ; Zoonosis ; Viral Infection
• 刊名：Gastroenterology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：150
• 期：2
• 页码：355-357.e3
• 全文大小：1307 K

文摘

There have been increasing reports of food-borne zoonotic transmission of hepatitis E virus (HEV) genotype 3, which causes chronic infections in immunosuppressed patients. We performed phylogenetic analyses of the HEV sequence (partial and full-length) from 1 patient from the Middle East who underwent liver transplantation, and compared it with other orthohepevirus A sequences. We found the patient to be infected by camelid HEV. This patient regularly consumed camel meat and milk, therefore camelid HEV, which is genotype 7, might infect human beings. Our finding links consumption of camel-derived food products to post-transplantation hepatitis E, which, if detected at early stages, can be cured with antiviral therapy and reduced administration of immunosuppressive agents.