How microglia kill neurons
详细信息 查看全文
- 作者：Guy C. Brown ; gcb3@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Anna Vilalta
- 关键词：BDNF ; brain-derived neurotrophic factor ; casp8 ; caspase 8 ; Cox-2 ; cyclooxygenase-2 ; CXCL1 ; chemokine (C-X-C motif) ligand 1 ; CX3CR1 ; CX3C chemokine receptor 1 ; DAP12 ; DNAX-activation protein 12 ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; HMGB1 ; high-mobility group protein B1 ; HSP60 ; heat shock protein 60 ; IGF1 ; insulin-like growth factor 1 ; INF-γ ; interferon-γ ; IL ; interleukin ; LPS ; lipopolysaccharide ; mito ; mitochondria ; MERTK ; Mer tyrosine kinase ; MFG-E8 ; milk fat globule-EGF factor 8 pr
- 刊名：Brain Research
- 出版年：2015
- 出版时间：2 December 2015
- 年：2015
- 卷：1628
- 期：part_PB
- 页码：288-297
- 全文大小：944 K
文摘
- •
Microglia are brain macrophages, activated by pathogens, damage or cytokines.
- •
10">Activated microglia kill neurons via TNFα, cathepsin B, glutamate, NO and oxidants.
- •
15">These agents may also protect neurons, and can only kill in specific circumstances.
- •
Stressed neurons can be killed by being phagocytosed by activated microglia.