The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish

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• 作者：Vincenzo Torraca ; Natasja A. Otto ; Aidin Tavakoli-Tameh ; Annemarie H. Meijer ; ^{a.h.meijer@biology.leidenuniv.nl}
• 关键词：Neutrophil chemotaxis ; Mycobacterium marinum ; Inflammatory chemokine ; Zebrafish ; Innate immunity ; Leukocyte biology
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：57-65
• 全文大小：1621 K
• 卷排序：67

文摘

The zebrafish chemokine Cxcl18b is chemotactic towards neutrophils. Cxcl18b requires expression of Cxcr2 to elicit neutrophil recruitment. During infection, Cxcl18b is induced in cells neighbouring the infectious focus. Cxcl18b is expressed by uninfected stromal cells within M. marinum granulomas.