Corticotropin-releasing factor in the locus coeruleus as a modulator of ventilation in rats
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- 作者：Jolene M. Incheglua ; b ; Kê ; nia Cardoso Bí ; cegoa ; b ; Luciane H. Gargaglionia ; b ; lucihel@fcav.unesp.br" class="auth_mail" title="E-mail the corresponding author ; lucihel@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Locus coeruleus ; CRF receptors ; Hypercapnia ; Ventilation ; Chemoreception
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：233
- 期：Complete
- 页码：73-80
- 全文大小：2167 K
文摘
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CRF1 antagonist in the locus coeruleus increases ventilation during normocapnia and hypercapnia.
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CRF acting on CRF1 receptors in the locus coeruleus exerts a tonic inhibitory role in ventilation.
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CO2-drive to breathing is attenuated by CRF in the locus coeruleus.