Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism
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- 作者：Matthieu Hammer1 ; 4 ; Dilja Krueger-Burg1 ; 4 ; Liam Patrick Tuffy1 ; Benjamin Hillman Cooper1 ; Holger Taschenberger1 ; Sarit Pati Goswami3 ; Hannelore Ehrenreich2 ; Peter Jonas3 ; Frederique Varoqueaux1 ; 5 ; Jeong-Seop Rhee1 ; rhee@em.mpg.de" class="auth_mail" title="E-mail the corresponding author ; Nils Brose1 ; brose@em.mpg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：13
- 期：3
- 页码：516-523
- 全文大小：2260 K
文摘
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Nlgn4 KO alters the composition of perisomatic inhibitory synapses in hippocampus
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Inhibitory synaptic transmission is impaired in Nlgn4 KO hippocampal area CA3
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Nlgn4 KO strongly perturbs oscillatory network activity in hippocampal area CA3
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Altered GABAergic signaling may link Nlgn4 loss-of-function mutations to autism