Stereochemical determination of new cytochalasans from the plant endophytic fungus Trichoderma gamsii

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• 作者：Lin Chen^a ; ^{lchenchina@163.com" class="auth_mail} ; Yue-Tao Liu^a ; Bo Song^a ; Hong-Wu Zhang^a ; Gang Ding^a ; ^b ; ^{gding@implad.ac.cn" class="auth_mail} ; Xing-Zhong Liu^c ; Yu-Cheng Gu^d ; Zhong-Mei Zou^a ; ^{zmzou@implad.ac.cn" class="auth_mail}
• 关键词：Endophytes ; Trichoderma gamsii ; Cytochalasans ; Stereochemistry
• 刊名：Fitoterapia
• 出版年：July 2014
• 年：2014
• 卷：96
• 期：Complete
• 页码：115-122
• 全文大小：869 K

文摘

Three new cytochalasans, trichalasins E (1), F (2) and H (7), together with four known analogues, trichalasin C (3), aspochalasin K (4), trichalasin G (5) and aspergillin PZ (8), were isolated from one endophytic fungus Trichoderma gamsii inhabiting in the traditional medicinal plant Panax notoginseng (BurK.) F.H. Chen. Trichalasins E (1) contains a unique hydroperoxyl group, which is the first report in all known analogues, whereas trichalasin H (7) possesses the rare 6/5/6/6/5 pentacyclic skeleton with 12-oxatricyclo [6.3.1.0^2,7] moiety as that of aspergillin PZ (8). The relative configurations of the new compounds were characterized by analysis of coupling constants and ROESY correlations, and the absolute configurations of trichalasins E (1), H (7) and aspergillin PZ (8) were determined by modified Mosher’s reaction. In addition, compounds 1–5, 7 and 8 were tested cytotoxic activities against several cancer cell lines.