- 作者：Zarko Alfirevic ; Hatem A. Mousa ; Vanessa Martlew ; Lesley Briscoe ; Marga Perez-Casal ; Cheng Hock Toh
- 刊名：Obstetrics and Gynecology
- 出版年：2001
- 出版时间：May 2001
- 年：2001
- 卷：97
- 期：5, Part 1
- 页码：753-759
- 全文大小：181 K
Methods: We studied 102 women who had pregnancy complications and 44 healthy women with uncomplicated pregnancies. All women were tested 10 weeks postpartum for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR) C677T, and G20210A prothrombin gene; deficiencies of protein C, protein S, and antithrombin III; and the presence of lupus anticoagulant and anticardiolipin antibodies. We aimed to recruit 100 cases and 300 controls to detect a 10 % difference in thrombophilia between the groups. However, we were able to recruit only 44 controls.
Results: Abnormal thrombophilia screen was found in 54 women with pregnancy complications (53 % ) and in 17 women (39 % ) with normal pregnancies (odds ratio [OR] 1.8; 95 % confidence interval [CI] 0.87, 3.67). Mutations encoding for factor V Leiden, G20210A prothrombin gene, and MTHFR C677T (homozygous) were identified in 18 % of women with complications compared with 16 % of controls (OR 1.1; 95 % CI 0.44, 2.94). Activated protein C resistance, not due to factor V Leiden mutation, was the most common thrombophilic defect, found in 26 % of women with pregnancy complications compared with 18 % of controls (OR 1.5; 95 % CI 0.63, 3.73). Twenty women with complications (20 % ) had multiple thrombophilic defects compared with four controls (9 % ) (OR 2.4; 95 % CI 0.78, 7.61).
Conclusion: In our cohort of women with pregnancy complications, maternal thrombophilia was less common than previously thought, and multiple thrombophilias were not a major additional risk factor.