Fructose-Rich Beverage Intake and Central Adiposity, Uric Acid, and Pediatric Insulin Resistance

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• 作者：Wei-Ting Lin ; MS¹ ; Te-Fu Chan ; MD ; PhD² ; ³ ; Hsiao-Ling Huang ; PhD⁴ ; Chun-Ying Lee ; MD ; MS⁵ ; ⁶ ; Sharon Tsai ; MS⁷ ; Pei-Wen Wu ; MS⁵ ; Yu-Cheng Yang ; MS⁵ ; Tsu-Nai Wang ; PhD⁵ ; Chien-Hung Lee ; PhD⁵ ; ⁸ ; ^{cnhung@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BMI ; Body mass index ; BSD ; Bottled sugar-containing drink ; FPG ; Fasting plasma glucose ; FSI ; Fasting serum insulin ; HFCS ; High-fructose corn syrup ; HOMA ; Homeostatic model assessment ; HOMA1 ; Original HOMA ; HOMA1-IR ; HOMA1 of IR ; HOMA1-%B ; HOMA1 of percentage beta cell function ; HOMA2 ; Updated nonlinear HOMA ; HOMA2-IR ; HOMA2 of IR ; HOMA2-%B ; HOMA2 of percentage beta cell function ; HSD ; Hand-shaken sugar-containing drink ; IR ; Insulin resistance ; MET ; Metabolic equivalent task ; mRP-aMS ; Multilevel
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：171
• 期：Complete
• 页码：90-96.e1
• 全文大小：330 K

文摘

To determine the association between sugar-sweetened beverage (SSB) consumption with biomarkers of insulin resistance (IR) and investigate whether/how this relates to obesity and serum uric acid in adolescents.

Study design

Adolescents (n = 1454, aged 12-16 years) were assessed in a study conducted to monitor Multilevel Risk Profiles for Adolescent Metabolic Syndrome in Taiwan. Detailed information about demographics, diet, physical, anthropometric, and clinical variables was collected. An original homeostatic model assessment of IR (HOMA1-IR), updated nonlinear homeostatic model assessment of IR (HOMA2-IR) model, and several IR markers were measured.

Results

Adolescents who consumed a greater amount of SSBs were more likely to have elevated fasting serum insulin, HOMA1-IR, and HOMA2-IR (P for trends, ≤.028). Compared with SSB nondrinkers, those with >350 mL/d intake of heavy high-fructose corn syrup-containing SSBs had a 0.52 and 0.30 higher multivariate-adjusted HOMA1-IR and HOMA2-IR, respectively. Waist circumference and serum uric acid were correspondingly found to explain 25.4% and 23.6%, as well as 23.2% and 20.6%, of the increases in the 2 IR markers. Both the elevations of HOMA1-IR and HOMA2-IR for high-fructose corn syrup-rich SSB intake were strengthened among obese adolescents (P for interaction, ≤.033).

Conclusions

Fructose-rich SSB intake is associated with elevated levels of IR, and this relationship may be partially mediated by central adiposity and serum uric acid. Obesity may modify the effect of this type of SSB consumption in intensifying the elevation of IR in adolescents.