Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris

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• 作者：Ta-Yuan Whuang^a ; ^b ; ^&dagger ; ; Wen-Cheng Tsai^c ; ^&dagger ; ; Nan-Fu Chen^d ; ^e ; ^&dagger ; ; Zhi-Cheng Chen^f ; Kuan-Hao Tsui^g ; ^h ; ⁱ ; Zhi-Hong Wen^f ; ^j ; Yin-Di Su^b ; Yu-Chia Chang^b ; ^j ; Yu-Hsin Chen^b ; ^k ; Mei-Chin Lu^a ; ^b ; Lee-Shing Fang^l ; Jih-Jung Chenⁱ ; Tung-Ying Wu^m ; Yang-Chang Wu^m ; ⁿ ; ^o ; ^p ; ^{yachwu@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Ping-Jyun Sung^a ; ^b ; ^f ; ^m ; ^p ; ^{pjsung@nmmba.gov.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Nephthea columnaris ; 19-Norsterol ; Columnaristerol ; Cytotoxicity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 October 2016
• 年：2016
• 卷：26
• 期：20
• 页码：4966-4969
• 全文大小：600 K

文摘

Columnaristerol A (1), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia–lymphoma cell lines.