Immunogenicity difference between two hepatitis E vaccines derived from genotype 1 and 4
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- 作者：Jiyue Wena ; Nouredine Behloula ; Xing Daib ; Chen Donga ; Jiuhong Lianga ; Min Zhangb ; Chengbo Shic ; Jihong Menga ; jihongmeng@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis E virus ; Vaccine ; Neutralization epitopes ; Monoclonal antibodies
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：128
- 期：Complete
- 页码：36-42
- 全文大小：1646 K
文摘
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We analyzed immunogenicity difference between p239 and p179 HEV vaccines.
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We assessed this difference using HEV antigens derived from different HEV genotypes.
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p239-induced IgGs reacted strongly against HEV genotype 1 and 2-generated antigens.
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p179-induced IgGs reacted strongly against HEV genotype 3 and 4- derived antigens.
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This difference is due to the presence of genotype-specific neutralizing epitopes.