Chenodeoxycholic acid reduces feed intake and modulates the expression of hypothalamic neuropeptides and hepatic lipogenic genes in broiler chickens
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- 作者：Alissa Piekarskia ; Eddy Decuypereb ; Johan Buyseb ; Sami Dridia ; dridi@uark.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; acetyl-CoA carboxylase ; ADPN ; adiponectin ; Adip-R1/2 ; adiponectin receptor 1 and 2 ; AgRP ; agouti-related peptide ; ATPcl ; ATP citrate lyase ; BW ; body weight ; CDCA ; chenodeoxycholic acid ; CRH ; corticotropin releasing hormone ; CXR ; chicken xenobiotic-sensing receptor ; FAS ; fatty acid synthase ; FI ; feed intake ; FXR ; farnesoid X receptor ; Ghrl ; ghrelin ; LXR ; liver X receptor ; MC1R ; melanocortin receptor 1 ; ME ; malic enzyme ; NPY ; neuropeptide Y ; ORX ; orexin ; ORXR ; orexin receptor ; PPAR ; peroxisom
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：229
- 期：Complete
- 页码：74-83
- 全文大小：1293 K
文摘
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Diet-containing CDCA inhibits feed intake and reduces body weight in broiler chickens.
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CDCA treatment modulates the expression of hypothalamic neuropeptides.
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CDCA alters the expression of hepatic lipogenic genes.
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CDCA modulates the expression of the hepatic adipokine; leptin, visfatin and adiponectin genes.