High homocysteine, low vitamin B-6, and increased oxidative stress are independently associated with the risk of chronic kidney disease
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- 作者：Cheng-Hsu Chen ; M.D. ; Ph.D.a ; b ; c ; d ; Wen-Ching Yang ; M.S. ; R.D.e ; Yu-Hua Hsiao ; M.S.f ; g ; Shih-Chien Huang ; Ph.D.f ; g ; Yi-Chia Huang ; Ph.D. ; R.D.f ; g ; ych@csmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Homocysteine ; Folate ; Vitamin B-6 ; Oxidative stress ; Antioxidant enzyme activities ; Chronic kidney disease
- 刊名：Nutrition
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：32
- 期：2
- 页码：236-241
- 全文大小：313 K
文摘
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This was a case-control study, and 97 patients with chronic kidney disease and 135 healthy subjects were recruited.
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Case subjects had significantly higher plasma homocysteine and oxidative stress but lower serum folate and plasma pyridoxal 5′-phosphate concentrations than control subjects.
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We found that high plasma homocysteine, low vitamin B-6, increased oxidative stress, and decreased antioxidant enzyme activity were independently contributed to development of early stage chronic kidney disease.