- 作者：Luca Busetto ; M.D.a ; luca.busetto@unipd.it ; Dario Mirabelli ; M.D.b ; Maria Letizia Petroni ; M.D.c ; Marco Mazza ; M.D.a ; Franco Favretti ; M.D.a ; Gianni Segato ; M.D.a ; Monica Chiusolo ; M.D.b ; Franco Merletti ; M.D.b ; Franco Balzola ; M.D.c ; Giuliano Enzi ; M.D.a
- 关键词：Morbid obesity ; Mortality ; Gastric banding
- 刊名：Surgery for Obesity and Related Diseases
- 出版年：2007
- 出版时间：September-October 2007
- 年：2007
- 卷：3
- 期：5
- 页码：496-502
- 全文大小：216 K
Background
To compare the mortality rate of obese patients treated by laparoscopic gastric banding (LAGB) with the mortality rate of matched obese patients observed at medical centers. The net effect of bariatric surgery on total mortality is still controversial. Gastric bypass has been shown to reduce the relative risk of death, but similar data with LABG are still lacking.Methods
The surgical series was composed of 821 patients with a body mass index (BMI) >40 kg/m2 consecutively treated with LAGB at Padova University, Italy. The reference group was composed of 821 gender-, age-, and BMI-matched patients selected from a sample of 4681 adults with a BMI >40 kg/m2 observed at 6 Italian medical centers not using surgical therapy.
Results
The mean follow-up was 5.6 ¡À 1.9 and 7.2 ¡À 1.2 years in the surgical and reference group, respectively. The vital status was known in 97.6 % of the surgical group (8 deaths) and in 97.4 % of the reference group (36 deaths). In the surgical group, the percentage of excess weight loss was 39.8 % ¡À 17.9 % 1 year after LAGB and 37.2 % ¡À 23.8 % 5 years after LAGB. The rate of late revisional surgery was 12.2 % . Survival was estimated using the Kaplan-Meier method, and the differences between the 2 groups were evaluated using the log-rank test. The survival rate was significantly greater in the surgical group (P = 0.0004). On multivariate Cox analysis, the 5-year relative risk of death in the surgical group, adjusted for gender, age, and baseline BMI, was 0.36 (95 % confidence interval 0.16?.80).
Conclusion
LAGB was associated with a 0 % operative mortality rate and 40 % stable excess weight loss. LAGB patients had a 5-year 60 % lower risk of death than comparable morbidly obese patients.