Novel triterpenoid AECHL-1 induces apoptosis in breast cancer cells by perturbing the mitochondria-endoplasmic reticulum interactions and targeting diverse apoptotic pathways
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- 作者：Mithila A. Sawanta ; Aparajita Dasguptaa ; Manish S. Lavhaleb ; Sandhya L. Sitasawada ; ssitaswad@nccs.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：AECHL-1 ; Ailanthus excelsa chloroform extract-1 ; ER ; Endoplasmic reticulum ; PERK ; Protein Kinase R-like ER kinase ; eIF2α ; eukaryotic Initiation Factor 2α ; ROS ; Reactive Oxygen Species ; Nrf2 ; Nuclear factor (erythroid-derived 2)-like factor 2 ; GSH ; Glutathione ; 4-PBA ; 4-Phenylbutyrate ; ISRIB ; Integrated Stress Response inhibitor ; AIF ; Apoptosis Inducing Factor ; DHE ; Dihydroethidium ; TMRE ; tetramethylrhodamine ; ethyl ester ; ZDF ; Z-DEVD-FMK
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1860
- 期：6
- 页码：1056-1070
- 全文大小：4443 K
文摘
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Molecular mechanism of an anticancer triterpenoid AECHL-1 is revealed.
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10">Upregulated ER stress by AECHL-1 is implicated in killing of breast cancer cells.
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15">Anticancer activity of AECHL-1 is driven via mitochondrial calcium accumulation.
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MCF-7 cells succumb to mitochondrial dysfunction and AIF mediated apoptosis.
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AECHL-1 targets MDA-MB-231cells by activation of extrinsic apoptotic pathway.