Estrogen-induced neuroprotective and anti-inflammatory effects are dependent on the brain areas of middle-aged female rats
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- 作者：Uday P. Pratap1 ; Anushree Patil1 ; Himanshu R. Sharma ; Lalgi Hima ; Ramanathan Chockalingam ; Murali M. Hariharan ; Sushrut Shitoot ; Hannah P. Priyanka ; Srinivasan ThyagaRajan ; thyagarajan.s@ktr.srmuniv.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tyrosine hydroxylase ; Nerve growth factor ; Cholinesterase ; ERK ; CREB ; Akt
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：238-253
- 全文大小：4857 K
文摘
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Estrogen increases the expression of p-TH, p-ERK, p-Akt, and p-CREB.
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Estrogen increases NO production and decreases TChE activity and p-NF-κB expression.
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Estrogen treatment increases the metabolic enzyme activities.
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Estrogen upregulates the antioxidant enzyme activities.