Centrally administered CDP-choline induced cardiovascular responses are mediated by activation of the central phospholipase-prostaglandin signaling cascade
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- 作者：Bora B. Topuza ; Burcin Altinbasa ; Tuncay Ilhanb ; Mustafa S. Yilmazc ; Hatice Erdostb ; Sikha Sahad ; Vahide Savcic ; Murat Yalcina ; mrtylcn75@gmail.com" class="auth_mail ; muraty@uludag.edu.tr" class="auth_mail
- 关键词：CDP-choline ; Prostaglandins ; Phopspholipase A2 ; Phopspholipase C ; Cyclooxygenase ; Blood pressure ; Heart rate ; Microdialysis ; Immunohistochemistry
- 刊名：Brain Research
- 出版年：14 May 2014
- 年：2014
- 卷：1563
- 期：Complete
- 页码：61-71
- 全文大小：2366 K
文摘
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CDP-choline clearly exerts pressor and bradycardic effect.
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CDP-choline causes the increase in total prostaglandins level and strong COXs immunoreactivity at hypothalamus.
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Phospholipase A2 and phospholipase C activity mediates the cardiovascular effect induced by CDP-choline.
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The inhibition of cyclooxygenase enzymes activity completely abolishes the cardiovascular effects of CDP-choline.
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The blockage of thromboxane synthesis significantly attenuates CDP-choline evoked cardiovascular responses.