Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions
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- 作者：Ioanna C. Vlachogiannia ; Elizabeth Fragopouloua ; George M. Stamatakisb ; Ioannis K. Kostakisc ; Smaragdi Antonopouloua ; antonop@hua.gr" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：PAF ; platelet-activating factor ; lyso PAF-AT ; acetyl-CoA ; lyso PAF acetyltransferase ; PAF-CP ; TDTT-insensitive ; CDP-choline ; 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase ; PAF-AH ; PAF- acetylhydrolase ; IL-1β ; interleukin-1β ; MAPK ; mitogen-activated protein kinase ; NF-κB ; nuclear factor kappa B ; DTT ; dithiothreitol
- 刊名：Prostaglandins and Other Lipid Mediators
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：121
- 期：part_PB
- 页码：176-183
- 全文大小：1052 K
文摘
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Tyrosol and resveratrol inhibit PAF production induced by IL-1β in U-937 cells.
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Tyrosol is more potent inhibitor than resveratrol.
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PAF levels after compounds incubation are mainly regulated by biosynthetic enzymes.
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Acetylation seems to retain inhibitory effect of tyrosol.
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Specific resveratrol acetylated derivatives exhibited dual action.