Assessing compartmentalized flux in lipid metabolism with isotopes
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- 作者：Doug K. Allen ; doug.allen@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC transporter ; ATP-binding cassette transporter ; ABCA9 ; ATP-binding (ABC) type transport protein ; acetyl-CoA ; acetyl-Coenzmye A ; ACP ; acyl carrier protein ; acyl-ACP ; acyl&ndash ; acyl carrier protein ; acyl-CoA ; acyl-Coenzyme A ; ADPG ; adenosine-diphosphate glucose ; aKG ; alpha-ketoglutarate ; AT ; acyltransferase ; Cho ; choline ; CoA ; coenzyme A ; CPT ; CDP-choline ; diacylglycerol cholinephosphotransferase ; DAG ; diacylglycerol ; DESI ; desorption electrospray ionization ; DGAT ; diacylglycerol acyltransferas
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1861
- 期：9
- 页码：1226-1242
- 全文大小：2425 K
文摘
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Isotopic labeling has provided numerous insights to lipid and central metabolism.
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Cellular heterogeneity and subcellular compartmentation complicate experiments.
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Stable isotopes with mass spectrometry can address current questions.
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Recent advances in metabolic flux analysis will benefit studies in lipid metabolism.