Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
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- 作者：Anna K. Bytzeka ; Gunda Koellenspergerb ; ; Bernhard K. Kepplera ; c ; Christian G. Hartingera ; c ; d ; c.hartinger@auckland.ac.nz" class="auth_mail" title="E-mail the corresponding author ;
- 关键词：BGE ; background electrolyte ; CZE ; capillary zone electrophoresis ; EPR ; electron paramagnetic resonance ; ESI ; electrospray ionization ; HSA ; human serum albumin ; MSA ; mouse serum albumin ; ICP ; inductively coupled plasma ; KP1019 ; indazolium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] ; Hind ; indazole ; LC ; liquid chromatography ; MALDI ; matrix assisted laser desorption/ionization ; MS ; mass spectrometry ; Na trans-[RuCl4(Hind)2] ; KP-1339/IT139 ; sodium trans-[tetrachloridobis(1H-indazole)ruthenat
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：160
- 期：Complete
- 页码：250-255
- 全文大小：668 K
文摘
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Biodistribution of a novel ruthenium anticancer agent in a mouse model
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Ru loading of mouse serum albumin as the main binding partner was determined.
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Novel capillary electrophoresis and liquid chromatography methods were applied.
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Similar behavior to KP1019 was observed for NKP-1339.