Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis

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• 作者：Mé ; lina L. Heuzé ; Isabelle Lamsoul ; Christel Moog-Lutz ; Pierre G. Lutz
• 关键词：Ubiquitin ; Proteasome ; E3 ligase ; Hematopoiesis ; Leukemogenesis
• 刊名：Blood Cells, Molecules, and Diseases
• 出版年：2008
• 出版时间：March-April 2008
• 年：2008
• 卷：40
• 期：2
• 页码：200-210
• 全文大小：475 K

文摘

Understanding the molecular mechanisms controlling normal hematopoietic differentiation is critical to develop new treatments for blood diseases and to manipulate stem cells. Despite the identification of many players in hematopoiesis, the molecular mechanisms controlling hematopoietic differentiation remain poorly understood. Due to a number of recent findings, the targeting of regulators of hematopoiesis to proteasomal degradation might be an important step in control of this developmental program.