Longitudinal Patterns of Thalidomide Neuropathy in Children and Adolescents

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• 作者：Wendy K.M. Liew ; MBChB ; MRCPCH¹ ; ² ; Christina A. Pacak ; PhD³ ; Nicole Visyak ; MA ; MS¹ ; Basil T. Darras ; MD¹ ; Athos Bousvaros ; MD ; MPH⁴ ; Peter B. Kang ; MD¹ ; ⁵ ; ^{pbkang@ufl.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Crohn disease ; thalidomide ; sensorimotor polyneuropathy
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：178
• 期：Complete
• 页码：227-232
• 全文大小：268 K

文摘

To characterize the longitudinal clinical and electrophysiological patterns of thalidomide neuropathy in children and adolescents.

Study design

Retrospective analysis of clinical records at a tertiary care children's hospital, including serial electrophysiological studies.

Results

Sixteen patients aged 6-24 years received thalidomide to treat Crohn's disease from 2002 to 2012. Nine subjects had electrophysiological evidence of sensorimotor axonal polyneuropathy, 8 of whom had sensory and/or motor symptoms. The patients with polyneuropathy received thalidomide for 5 weeks to 52 months, with cumulative doses ranging from 1.4 to 207.7 g. All subjects with cumulative doses greater than 60 g developed polyneuropathy, and 4 of the 5 subjects who received thalidomide for more than 20 months developed polyneuropathy. The 7 subjects who had normal neurophysiological studies received therapy for 1 week to 25 months, with cumulative doses ranging from 0.7 to 47 g. In contrast to some previous reports, several patients had sensorimotor polyneuropathies, rather than pure sensory neuropathies. In patients with neuropathy who received therapy for more than 24 months and had 3 or more electromyography studies, the severity of the neuropathy plateaued.

Conclusions

Factors in addition to the total dose may contribute to the risk profile for thalidomide neuropathy, including pharmacogenetic susceptibilities. The severity of the neuropathy does not worsen relentlessly. Children, adolescents, and young adults receiving thalidomide should undergo regular neurophysiological studies to monitor for neuropathy.