World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung

详细信息    查看全文

• 作者：Vasanthi R. Sunil^a ; ^{sunilva@pharmacy.rutgers.edu} ; Kinal N. Vayas^a ; Mingzhu Fang^b ; Helmut Zarbl^b ; Christopher Massa^a ; Andrew J. Gow^a ; Jessica A. Cervelli^a ; Howard Kipen^b ; Robert J. Laumbach^b ; Paul J. Lioy^b ; Jeffrey D. Laskin^b ; Debra L. Laskin^a
• 关键词：WTC ; World Trade Center ; i.t. ; intratracheal ; i.p. ; intraperitoneal ; HO-1 ; heme oxygenase-1 ; COX-2 ; cyclooxygenase-2 ; MMP-12 ; matrix metalloproteinase-12 ; BAL ; bronchoalveolar lavage ; PEEP ; positive end expiratory pressure ; COPD ; chronic obstructive pulmonary disease ; K ; lysine
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：50-58
• 全文大小：2021 K
• 卷排序：102

文摘

WTC dust causes pulmonary oxidative stress and inflammation in mice. WTC dust exposure results in specific methylation of histone H3 lysine and global changes in DNA methylation. Alterations in pulmonary mechanics are observed after WTC dust exposure.