The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson's disease

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• 作者：Carmen Rodriguez-Blazquez ; Jose Manuel Rojo-Abuin ; Mario Alvarez-Sanchez ; Tomoko Arakaki ; Alberto Bergareche-Yarza ; Anabel Chade ; Nelida Garretto ; Oscar Gershanik ; Monica M. Kurtis ; Juan Carlos Martinez-Castrillo ; Amelia Mendoza-Rodriguez ; Henry P. Moore ; Mayela Rodriguez-Violante ; Carlos Singer ; Barbara C. Tilley ; Jing Huang ; Glenn T. Stebbins ; Christopher G. Goetz ; Pablo Martinez-Martin
• 关键词：Parkinson's disease ; MDS-UPDRS ; Rating scales ; Disability ; Assessment
• 刊名：Parkinsonism and Related Disorders
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：19
• 期：10
• 页码：889-893
• 全文大小：298 K

文摘

Objective

To evaluate the motor experiences of daily living section of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS M-EDL) for assessing disability in PD patients; to determine the association between disability and quality of life; and to identify cut-off score ranges for no, mild, moderate and severe disability with this measure.

Methods

International, observational, cross-sectional study of 435 PD patients, assessed with: MDS-UPDRS, Hoehn and Yahr staging, Rapid Assessment of Disability Scale, Clinical Impression of Severity Index for PD, Parkinson's Disease Questionnaire-8 and EQ-5D. Descriptive statistics, Spearman's rank correlation coefficients, Kruskal-Wallis test for group comparisons, ordinal logistic regression analysis for setting cut-off values and a step-wise multiple linear regression model were calculated.

Results

MDS-UPDRS M-EDL correlated 0.70-0.80 with other disability measures, and??0.46 to 0.74 with quality of life scales. Scores significantly increased with higher disease duration and severity (p?<?0.001). Cut-off values for the M-EDL were: 0-2 points, no disability; 3-16, mild; 17-31, moderate; and 32 points or more, severe. Linear regression analysis identified the MDS-UPDRS nM-EDL section as the main determinant of M-EDL, followed by the rest of MDS-UPDRS sections (explained variance: 59 % ).

Conclusions

MDS-UPDRS M-EDL proved to be useful for assessing disability in PD.