Incorporating bolus and infusion pharmacokinetics into the ICING insulin model
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- 作者：Liam Fisk liam.fisk@pg.canterbury.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Paul D. Docherty ; paul.docherty@pg.canterbury.ac.nz" class="auth_mail" title="E-mail the corresponding author ; pauldocherty@xtra.co.nz" class="auth_mail" title="E-mail the corresponding author ; paul.docherty@canterbury.ac.nz" class="auth_mail" title="E-mail the corresponding author ; Christopher Pretty chris.pretty@pg.canterbury.ac.nz" class="auth_mail" title="E-mail the corresponding author ; J. Geoffrey Chase geoff.chase@pg.canterbury.ac.nz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Compartment model ; Insulin ; Pharmacokinetics ; Physiologic modelling
- 刊名：Mathematical Biosciences
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：281
- 期：Complete
- 页码：1-8
- 全文大小：830 K
文摘
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A model was developed for insulin kinetics and pharmacokinetics.
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It is the first model to adequately facilitate both insulin boluses and infusions.
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The model uses a mix of a priori and identified parameters to capture behaviour.
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The model was designed to be identifiable from sparse data sets in a clinical setting.