- 作者：Christos A. Venetis ; Efstratios M. Kolibianakis ; Konstantinos A. Toulis ; Dimitrios G. Goulis ; Ioannis Papadimas ; Basil C. Tarlatzis
- 关键词：Albumin ; prevention ; severe ovarian hyperstimulation syndrome ; metaanalysis
- 刊名：Fertility and Sterility
- 出版年：2011
- 出版时间：January 2011
- 年：2011
- 卷：95
- 期：1
- 页码：188-196.e3
- 全文大小：300 K
ass=""h4"">Objective
To reappraise the currently available evidence, providing the answer to the following question: does intravenous albumin administration reduce the risk of severe ovarian hyperstimulation syndrome (OHSS) occurrence following ovarian stimulation with gonadotrophins and GnRH analogues for IVF in high-risk patients?ass=""h4"">Design
Systematic review and metaanalysis.
ass=""h4"">Setting
University-based hospital.
ass=""h4"">Intervention(s)
Intravenous albumin administration in high-risk patients for prevention of severe OHSS occurrence.
ass=""h4"">Main Outcome Measure(s)
Severe OHSS occurrence.
ass=""h4"">Result(s)
Eight eligible randomized controlled trials were identified (n = 1,199 patients) that offered data for statistical pooling. No statistically significant difference in the occurrence of severe OHSS in patients who received intravenous albumin (n = 595) and those who did not (n = 604; odds ratio [OR], 0.80; 95 % confidence interval [CI], 0.52–1.22) was detected. Moreover, no statistically significant differences were present regarding the probability of pregnancy (OR, 0.83; 95 % CI, 0.64–1.07) and first trimester pregnancy loss (OR, 1.44; 95 % CI, 0.73–2.85) between patients who received intravenous albumin and those who did not.
ass=""h4"">Conclusion(s)
Based on the currently best available evidence, intravenous albumin administration in high-risk patients does not appear to reduce the occurrence of severe OHSS. This finding should be considered when implementing strategies for severe OHSS prevention.