Construction and immunological evaluation of recombinant Lactobacillus plantarum expressing HN of Newcastle disease virus and DC- targeting peptide fusion protein
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- 作者：Yanlong Jiang1 ; Jingtao Hu1 ; Yanbing Guo ; Wentao Yang ; Liping Ye ; Chunwei Shi ; Yuying Liu ; Guilian Yang ; yangguilian@jlau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chunfeng Wang ; wangchunfeng@jlau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：NDV ; HN protein ; DC-targeting peptide ; L. plantarum ; Immune response
- 刊名：Journal of Biotechnology
- 出版年：2015
- 出版时间：20 December 2015
- 年：2015
- 卷：216
- 期：Complete
- 页码：82-89
- 全文大小：1967 K
文摘
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We design a new fusion protein composed of NDV HN protein and a 12-mer DC cells targeting peptide (DCpep).
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Lactobacillus plantarum with an inducible vector pSIP409 is used to deliver the fusion protein to chicken.
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Results show that the inclusion of DCpep significantly increased the production of SIgA and CD4+ cells.