Noncanonical NF-κB Signaling in Health and Disease

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• 作者：Gö ; khan Cildir¹ ; ² ; ⁴ ; Kee Chung Low¹ ; ⁴ ; Vinay Tergaonkar¹ ; ² ; ³ ; ^{vinayt@imcb.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author}
• 关键词：non-canonical NF-κB signaling ; NIK ; p52/RelB
• 刊名：Trends in Molecular Medicine
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：22
• 期：5
• 页码：414-429
• 全文大小：2181 K

文摘

Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under normal physiological conditions, this noncanonical pathway has been implicated in diverse biological processes, including lymphoid organogenesis, B cell maturation, osteoclast differentiation, and various functions of other immune cells. Recently, dysfunction of this pathway has also been causally associated with numerous immune-mediated pathologies and human malignancies. Here, we summarize the core elements as well as the recently identified novel regulators of the noncanonical NF-κB signaling pathway. The involvement of this pathway in different pathologies and the potential therapeutic options that are currently envisaged are also discussed.