Inhibitory effects and mechanism of 25-OH-PPD on glomerular mesangial cell proliferation induced by high glucose
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- 作者：Junxian Yua ; Chunna Liub ; Zhe Lia ; Chao Zhanga ; Zheng Wanga ; Xinyu Liuc ; springnanaliu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：25-OH-PPD ; Glomerular mesangial cell ; High glucose level ; Diabetic nephropathy ; Oxidative stress ; Calcium transient ; COX-2
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：93-98
- 全文大小：940 K
文摘
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PPD has protective effects on GMC from HG-induced hypertrophy.
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PPD could inhibit [Ca+]і transient and reduce the expression of COX-1.
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The mechanism is PPD inhibit oxidative-stress injure pathway reverse GMC proliferation.
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The study provide a new drug target for the diabetic nephropathy.