The volumetric and shape changes of the putamen and thalamus in first episode, untreated major depressive disorder
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- 作者：Yi Lua ; Hongmin Lianga ; Dan Hana ; Yin Moa ; Zongfang Lia ; Yuqi Chengb ; Xiufeng Xub ; Zonglin Shenb ; Chunyan Tana ; Wei Zhaoa ; Yun Zhua ; Xuejin Suna ; sunxuejinkm@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Major depressive disorder ; Volumetric analysis ; Shape analysis ; Putamen ; Thalamus
- 刊名：NeuroImage: Clinical
- 出版年：2016
- 出版时间：2016
- 年：2016
- 卷：11
- 期：Complete
- 页码：658-666
- 全文大小：1075 K
文摘
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Structural abnormalities in putamen and thalamus might be the potential trait marker of MDD at the early stage.
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The abnormality of LCSTC circuits, or LCSPT circuit, may contribute to the pathophysiology of MDD.
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The shape analysis is more sensitive to subtle structural changes than volumetric and VBM analysis.