- 作者：Erkan Iriz ; Meltem Yalinay Cirak ; Mustafa Hakan Zor ; Doruk Engin ; Levent Oktar ; Yusuf Unal
- 关键词：Chlamydia pneumoniae ; Cardiovascular ; Atherosclerosis ; Peripheral artery disease ; Nested PCR ; Ankle brachial index
- 刊名：Journal of Surgical Research
- 出版年：2013
- 出版时间：August, 2013
- 年：2013
- 卷：183
- 期：2
- 页码：537-541
- 全文大小：228 K
ss=""h4"">Background
We studied the existence of agents in aorta biopsies, such as Chlamydia pneumoniae, cytomegalovirus, and Mycoplasma pneumoniae, that are thought to have a role in atherosclerosis etiopathogenesis role, and their association with peripheral artery disease.ss=""h4"">Materials and methods
We examined aorta wall and internal mammarian artery (IMA) biopsies taken from two different places in 63 patients in whom coronary artery bypass was performed. In these biopsies, we evaluated the deoxyribonuclease (DNA) of these microorganisms using polymerase chain reaction. From the same patients, we recorded the ankle brachial index, road walking distance information, lipid profile, C-reactive proteins, blood parameters such as fibrinogen, and the patient¡¯s operation data.
ss=""h4"">Results
In the nine aorta biopsies taken from 63 patients, we isolated C pneumoniae DNA. In IMA biopsies taken from the same patients, we detected no microorganism DNA (P?<?0.001). In the same aorta biopsies, we found no cytomegalovirus or M pneumoniae DNA. We examined 12 patients using an index value of 0.9 in the ankle brachial index evaluation; eight had C pneumoniae in the aorta biopsies (P < 0.001).
ss=""h4"">Conclusions
We found a significant relationship between C pneumoniae DNA and the existence of peripheral artery disease. In the development of atherosclerosis with C pneumoniae, there may be a determinant pathogen in both the aorta and the peripheral arteries. The nonexistence of C pneumoniae DNA in the IMA biopsies may indicate infectious agents because of the predominant endothelial functions in this artery, and thus its resistance to atherosclerosis.