Role of GABA_A and GABA_B receptors in GABA-induced inhibition of rat red nucleus neurons

详细信息    查看全文

• 作者：Ciranna ; Lucia ; Licata ; Flora ; Li Volsi ; Guido ; Santangelo ; Francesca
• 关键词：GABA_A ; GABA_B ; Red nucleus ; Electrophysiology ; Microiontophoresis ; Motor control
• 刊名：Neuroscience Letters
• 出版年：2003
• 出版时间：May 8, 2003
• 年：2003
• 卷：341
• 期：3
• 页码：221-224
• 全文大小：95.5 K

文摘

We investigated GABA receptor subtypes mediating GABA-induced inhibition of red nucleus (RN) neuronal firing recorded extracellularly from anaesthetized rats. GABA response was mimicked by the GABA_A agonists muscimol and isoguvacine in all cases and was partially blocked by the GABA_A antagonist bicuculline. The GABA_B agonist baclofen induced a long-lasting inhibition in 84 % of cells. Neurons responding to either GABA_A or GABA_B agonists were equally distributed within the RN. The GABA_C receptor agonist cis-amino-crotonic acid (CACA) did not modify RN neuronal firing; at high doses CACA occasionally induced inhibition abolished by bicuculline and thus mediated by GABA_A receptors. We conclude that the inhibitory effects of GABA in the RN are mediated by both GABA_A and GABA_B receptors, whereas GABA_C receptors are not involved.