Disease specific enrichment of circulating let-7 family microRNA in MuSK + myasthenia gravis
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- 作者：Tanel Pungaa ; Emanuela Bartoccionib ; Marta Lewandowskac ; Valentina Damatod ; Amelia Evolid ; Anna Rostedt Pungac ; anna.rostedt.punga@neuro.uu.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：Muscle specific tyrosine kinase ; MuSK ; Myasthenia gravis ; MG ; MicroRNA ; Let-7 ; Biomarker
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：292
- 期：Complete
- 页码：21-26
- 全文大小：564 K
文摘
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We determined levels of serum circulating microRNAs in MuSK + MG patients.
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MiR-151a-3p, let-7a-5p, let-7f-5p and miR-423-5p are elevated in MuSK + MG sera.
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The microRNA profile in MuSK + MG differs from that reported in AChR + MG.
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Especially the let-7 microRNA family seems connected to MuSK + MG.