Circulating microRNAs meet the three key criteria of valuable biomarkers: measurability, validation and utility.

The analysis of circulating miRNAs is rapidly advancing and clinical applications are on the verge of becoming reality.

Careful pre-analytical planning and standardized protocols are required to generate bias-free and reproducible data.

Several studies have addressed the utility of circulating miRNAs as biomarkers in bone and other multifactorial diseases.

MicroRNA signatures could reflect skeletal as well as non-skeletal risk factors and accurately predict fracture-risk.