Abuse and diversion of buprenorphine sublingual tablets and film

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• 作者：Eric J. Lavonas ; M.D.^a ; ^{eric.lavonas@rmpdc.org" class="auth_mail} ; S. Geoffrey Severtson ; Ph.D.^a ; ^{geoff.severtson@rmpdc.org" class="auth_mail} ; Erin M. Martinez ; M.S.^a ; ^{erin.martinez@rmpdc.org" class="auth_mail} ; Becki Bucher-Bartelson ; Ph.D.^a ; ^{Becki.Bucher-Bartelson@rmpdc.org" class="auth_mail} ; Marie-Claire Le Lait ; M.S.^a ; ^{marie-claire.lelait@rmpdc.org" class="auth_mail} ; Jody L. Green ; Ph.D.^a ; ^{jody.green@rmpdc.org" class="auth_mail} ; Lenn E. Murrelle ; MSPH ; Ph.D.^b ; ^{lenn.murrelle@venebio.com" class="auth_mail} ; Theodore J. Cicero ; Ph.D.^c ; ^{cicerot@psychiatry.wustl.edu" class="auth_mail} ; Steven P. Kurtz ; Ph.D.^d ; ^{steven.kurtz@nova.edu" class="auth_mail} ; Andrew Rosenblum ; Ph.D.^e ; ^{rosenblum@ndri.org" class="auth_mail} ; Hilary L. Surratt ; Ph.D.^d ; ^{surratt@nova.edu" class="auth_mail} ; Richard C. Dart ; M.D. ; Ph.D.^a ; ^{richard.dart@rmpdc.org" class="auth_mail}
• 关键词：CI ; 95% Confidence interval ; FDA ; United States Food and Drug Administration ; IRB ; Institutional review board ; OTP ; Opioid Treatment Program ; REMS ; Risk evaluation and mitigation strategy ; SKIP ; Survey of Key Informants' Patients ; URDD ; Unique recipients of a dispensed drug ; US ; United States
• 刊名：Journal of Substance Abuse Treatment
• 出版年：July 2014
• 年：2014
• 卷：47
• 期：1
• 页码：27-34
• 全文大小：499 K

文摘

Buprenorphine abuse is common worldwide. Rates of abuse and diversion of three sublingual buprenorphine formulations (single ingredient tablets; naloxone combination tablets and film) were compared. Data were obtained from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS^®) System Poison Center, Drug Diversion, Opioid Treatment (OTP), Survey of Key Informants' Patients (SKIP), and College Survey Programs through December 2012. To control for drug availability, event ratios (rates) were calculated quarterly, based on the number of patients filling prescriptions for each formulation (“unique recipients of a dispensed drug,” URDD) and averaged and compared using negative binomial regression. Abuse rates in the OTP, SKIP, and College Survey Programs were greatest for single ingredient tablets, and abuse rates in the Poison Center Program and illicit diversion rates were greatest for the combination tablets. Combination film rates were significantly less than rates for either tablet formulation in all programs. No geographic pattern could be discerned.