Synthesis, structure and ADMET properties of the monoribbed-functionalized iron(II) clathrochelates with terminal DNA-relevant groups
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- 作者：Genrikh E. Zelinskiia ; Alexander S. Belova ; Anna V. Vologzhaninaa ; Alexander A. Pavlova ; Valentin V. Novikova ; Oleg A. Varzatskiib ; Yan Z. Voloshina ; c ; voloshin@ineos.ac.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：Macrocyclic compounds ; Clathrochelates ; Ligand reactivity ; Nucleophilic substitution ; Topological drugs ; ADMET properties
- 刊名：Inorganica Chimica Acta
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：448
- 期：Complete
- 页码：7-15
- 全文大小：1679 K
文摘
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Iron mono- and dichloroclathrochelates undergo substitution with functionalized amines.
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Nucleophilic substitution gave the clathrochelates with terminal DNA-relevant groups.
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Conformations of amine substituents are affected by intramolecular hydrogen bonding.