Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles
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- 作者：Amé ; lie Rezza1 ; 2 ; Zichen Wang1 ; 4 ; 5 ; Rachel Sennett1 ; 2 ; 4 ; Wenlian Qiao7 ; Dongmei Wang6 ; Nicholas Heitman1 ; 2 ; 4 ; Ka Wai Mok1 ; 2 ; Carlos Clavel1 ; 2 ; 8 ; Rui Yi6 ; Peter Zandstra7 ; Avi Ma&rsquo ; ayan1 ; 4 ; 5 ; Michael Rendl1 ; 2 ; 3 ; 4 ; michael.rendl@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：hair follicle ; hair growth ; progenitors ; dermal papilla ; stem cells ; stem cell niche ; epithelial-mesenchymal interactions ; transcriptomics ; systems biology ; big data ; signaling networks
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：29 March 2016
- 年：2016
- 卷：14
- 期：12
- 页码：3001-3018
- 全文大小：9886 K
文摘
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RNA-seq identifies transcriptomes of 14 skin populations during hair growth
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SC precursors, progenitors, and hair-type-specific DP niche signatures are defined
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Comparison with embryonic and adult signatures shows dynamic gene expression
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Signaling interaction network reveals a complex web of intercellular exchanges