High-throughput sequencing in acute lymphoblastic leukemia: Follow-up of minimal residual disease and emergence of new clones

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• 作者：Mikaë ; l Salson^a ; ¹ ; ^{contact@vidjil.org} ; Mathieu Giraud^a ; ¹ ; ^{contact@vidjil.org} ; Auré ; lie Caillault^b ; ¹ ; ^{aurelie.caillault@chru-lille.fr} ; Nathalie Grardel^b ; ¹ ; ^{nathalie.grardel@chru-lille.fr} ; Nicolas Duployez^b ; Yann Ferret^b ; Marc Duez^c ; Ryan Herbert^a ; Tatiana Rocher^a ; Shé ; hé ; razade Sebda^d ; Sabine Quief^d ; Cé ; line Villenet^d ; Martin Figeac^d ; ^e ; Claude Preudhomme^b ; ^{claude.preudhomme@chru-lille.fr}
• 关键词：Acute lymphoblastic leukemia ; Minimal residual disease ; Follow-up ; Repertoire sequencing ; Bioinformatics
• 刊名：Leukemia Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：53
• 期：Complete
• 页码：1-7
• 全文大小：1895 K
• 卷排序：53

文摘

Repertoire sequencing (RepSeq) gives a deep insight of leukemic lymphoid populations. High-throughput sequencing identifies new emerging clones at the time of relapse. Clones of low abundance at diagnosis may become relapsing clones. The Vidjil software enables both automated and interactive analysis of RepSeq data.